By Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman

ISBN-10: 0849398703

ISBN-13: 9780849398704

ISBN-10: 1420021044

ISBN-13: 9781420021042

Because the 3rd prime explanation for dying within the usa, stroke debts for one in each fifteen deaths and is the main reason behind incapacity within the kingdom. Compiled by way of a popular editorial group, this reference bridges the space among simple technology and sufferer care protocols, and collects forty three expertly written chapters that diversity from laboratory-based study on animal versions to the development, mechanisms, therapy, and diagnosis of illnesses corresponding to subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and international cerebral ischemia.

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Additional resources for Acute Stroke: Bench to Bedside (Neurological Disease and Therapy)

Sample text

Due to these observations, the relevance of these models to human 2 PRADILLA ET AL. cerebral vasospasm has been questioned (25), and the injection and clot-placement models in animals remain more suitable alternatives. IN VIVO MODELS OF VASOSPASM Animal models of SAH have been used extensively to induce vasospasm and include multiple species and diverse techniques. —can differ from one species to another. CREATION OF SAH AND INDUCTION OF VASOSPASM Models of SAH should ideally consist of placement or injection of blood that surrounds a cerebral artery and results in consistent and reproducible, delayed vasospasm that lasts for several days, as confirmed by angiographic or morphometric analysis.

Stroke 1982; 13:368–379. 106. Schwartz SM, deBlois D, O’Brien ER. The intima. Soil for atherosclerosis and restenosis. Circ Res 1995; 77:445– 465. 107. Barry KJ, Gogjian MA, Stein BM. Small animal model for investigation of subarachnoid hemorrhage and cerebral vasospasm. Stroke 1979; 10:538–541. 108. Shiguma M. Change in the ionic environment of cerebral arteries after subarachnoid hemorrhage. Especially of potassium ion concentration in subarachnoid hematoma and its role in cerebral vasospasm.

Macdonald RL, Curry DJ, Aihara Y, Zhang ZD, Jahromi BS, Yassari R. Magnesium and experimental vasospasm. J Neurosurg 2004; 100:106–110. 12. Robertson EG. Cerebral lesions due to intracranial aneurysms. Brain 1949; 72:150–185. 13. Ecker A, Riemenschneider PA. Arteriographic demonstration of spasm of the intracranial arteries with special reference to saccular arterial aneurysms. J Neurosurg 1951; 8:660 – 667. 14. Conway LW, McDonald LW. Structural changes of the intradural arteries following subarachnoid hemorrhage.

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Acute Stroke: Bench to Bedside (Neurological Disease and Therapy) by Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman


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